Masters Project Offered in Campylobacter jejuni Genome Analysis

Topic: Investigation into Campylobacter jejuni infection sources: analysis of genome data from isolates collected over four years from multiple sources Description: Campylobacter jejuni is a foodborne pathogen causing human diseases ranging from food poisoning to sepsis. Campylobacter is often caught, or assumed to be caught, from eating chicken and poultry. Most countries have a peak of cases in Summer, but German-speaking countries also have a peak in Winter. We wanted to find out why, and if Fondue Chinoise is responsible. Using whole genome sequencing, providing the highest level of discrimination between isolates, we have obtained data on isolates from patients, chicken meat and other sources. The project requires a careful bioinformatic analysis and comparison of over 600 genomes to infer infection sources, investigate virulence factors and determine antimicrobial resistance rates. Requirements: Interest in microbial genomics bioinformatics; command line and HPC knowledge; prepared for predominantly computer based project. Specific bioinformatic methods will be researched / taught. Please Note: There is no funding associated with this project. Ideally you will already be enrolled at the UZH (https://www.uzh.ch/en/studies/programs/master.html) or a local University / Fachhochschule. In terms of living costs, the university recommends that students have around 3000 CHF per month to live in Zurich. Application: Please contact PD Dr Helena Seth-Smith with your CV if interested.