Masters Project Offered in Genome Data Analysis from Sequence-Captured Samples

Topic: Analysing bacterial genome data from clinical samples: finding the best tools to analyse sequence capture data. Description: Many bacteria cannot be grown easily in the laboratory, making their genomes hard to sequence. We are using sequence capture / target enrichment techniques to obtain genome data on panels of syndromically related bacteria, such as those causing sexually transmitted infections. We have great data covering complete genomes of target bacterial pathogens, but also with human and other bacterial contamination. In order to best disentangle the data, to be able to analyse each species as well as possible, we want to find the best tools. This project will use existing sequence data to analyse in multiple ways to find the best analytical tools. Requirements: Interest in microbial genomics bioinformatics; command line and HPC knowledge; prepared for predominantly computer based project. Specific bioinformatic methods will be researched / taught. Please Note: There is no funding associated with this project. Ideally you will already be enrolled at the UZH (https://www.uzh.ch/en/studies/programs/master.html) or a local University / Fachhochschule. In terms of living costs, the university recommends that students have around 3000 CHF per month to live in Zurich. Application: Please contact PD Dr Helena Seth-Smith with your CV if interested.